All content published by the American Metabolic Research Institute undergoes a structured editorial and peer review process. We adhere to evidence-based standards aligned with GRADE methodology and ICMJE recommendations, and maintain a clear separation between primary research, systematic review, and educational commentary.

1. Content Categories

AMRI publishes three categories of content, each subject to distinct review requirements:

Evidence Synthesis

Systematic reviews and meta-analyses of RCT data. Requires full PRISMA-compliant methodology, dual-reviewer extraction, and statistical verification.

Clinical Review

Narrative reviews of published trial data and pharmacological mechanisms. Requires primary source verification and peer review by a qualified researcher.

Educational Content

Patient and clinician education material. Reviewed for accuracy against current guidelines and FDA-approved labelling. Clearly distinguished from primary research.

2. Peer Review Process

All clinical review and evidence synthesis content is subject to internal peer review by at least one qualified AMRI researcher prior to publication. Review assesses: accuracy of data representation, appropriate contextualisation of effect sizes and confidence intervals, completeness of safety information, and compliance with our conflict of interest policy.

Statistical claims are verified directly against published trial tables or clinicaltrials.gov result datasets. Where figures are derived from pooled analyses or indirect comparisons, this is explicitly noted in the published content.

3. Evidence Grading

AMRI uses a simplified GRADE-aligned framework for characterising the certainty of evidence cited:

Grade	Definition	Typical Source
High	Confident the estimate reflects the true effect	Large RCTs, consistent systematic reviews
Moderate	Estimate likely close to true effect; some uncertainty	RCTs with limitations, consistent cohort studies
Low	True effect may differ substantially from estimate	Observational studies, indirect comparisons
Very Low	Little confidence in the estimate	Case reports, mechanistic extrapolation

4. Data Accuracy and Illustrative Figures

Clinical data figures cited in AMRI reviews (e.g., percentage weight loss, hazard ratios, p-values) are sourced directly from published peer-reviewed literature. Where figures are used illustratively to represent a range or typical finding rather than a specific trial result, this is explicitly flagged with a note. We do not present illustrative data as primary trial outcomes.

5. Updates and Corrections

Medical evidence evolves. Published articles are reviewed for currency on an annual cycle, or sooner if significant new trial data or regulatory changes occur. The date of last review is displayed on every article. If a factual error is identified, a correction notice is published alongside the updated content within 14 business days of confirmation. Substantive errors that affect clinical interpretation trigger a prominent correction header on the affected page.

To report a potential inaccuracy, contact: [email protected]

6. Advertising and Sponsored Content

AMRI does not publish sponsored content, native advertising, or advertorial material. Any display advertising present on the site is clearly distinguished from editorial content and has no influence on research selection or framing. Advertisers have no access to editorial decisions.

Editorial enquiries:
[email protected]
American Metabolic Research Institute — 200 Innovation Way, Suite 400, Boston, MA 02110

Editorial Standards and Review Methodology